Glycosylphosphatidylinositol-Anchored Immunoglobulin Superfamily Cell Adhesion Molecules and Their Role in Neuronal Development and Synapse Regulation
نویسندگان
چکیده
Immunoglobulin superfamily (IgSF) cell adhesion molecules (CAMs) are cell surface glycoproteins that not only mediate interactions between neurons but also between neurons and other cells in the nervous system. While typical IgSF CAMs are transmembrane molecules, this superfamily also includes CAMs, which do not possess transmembrane and intracellular domains and are instead attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor. In this review, we focus on the role GPI-anchored IgSF CAMs have as signal transducers and ligands in neurons, and discuss their functions in regulation of neuronal development, synapse formation, synaptic plasticity, learning, and behavior. We also review the links between GPI-anchored IgSF CAMs and brain disorders.
منابع مشابه
Reciprocal Interactions between Cell Adhesion Molecules of the Immunoglobulin Superfamily and the Cytoskeleton in Neurons
Cell adhesion molecules of the immunoglobulin superfamily (IgSF) including the neural cell adhesion molecule (NCAM) and members of the L1 family of neuronal cell adhesion molecules play important functions in the developing nervous system by regulating formation, growth and branching of neurites, and establishment of the synaptic contacts between neurons. In the mature brain, members of IgSF re...
متن کاملNeural GPI-anchored cell adhesion molecules.
When first identified, neural cell adhesion molecules (neural CAMs) were thought to act simply by providing cell surfaces with differential adhesion properties. In the decades following the identification of the first neural CAMs, it has been realized that these proteins are actually involved in very complex processes such as axon guidance, neuronal migration, neurite outgrowth and fasciculatio...
متن کاملNeuronal synapse formation regulated by intercellular adhesion molecules-5 (ICAM-5)
.................................................................................................................... 9 REVIEW OF THE LITERATURE .................................................................................. 10 1. Synapses and spines ............................................................................................... 10 1.1 Ultrastructure of synapses .................
متن کاملIntroduction: Cell adhesion and extracellular matrix molecules in synaptic plasticity.
This issue of Neuron Glia Biology contains a special collection of original research papers and reviews on the role of cell adhesion and extracellular matrix (ECM) molecules in synaptic plasticity. These molecules are crucially required for building and maintaining synaptic structure during brain development and there is increasing evidence that they also play important roles in modulating dist...
متن کاملResearch Article
The cell-cell adhesion systems are involved in neuronal cell migration, axon-bundle formation, target-cell recognition, activity-dependent plasticity of synapses, and formation of complex glial networks, which surround axons and synapses (for a review, see Redies and Takeichi, 1996). The cell-cell adhesion molecules implicated in brain function are classified into two superfamilies, the cadheri...
متن کامل